Saturday, October 27, 2007

BACKGROUND AND RATIONALE
ARTEMINISIN is being shown by itself and in combination therapies or treatments to provide a broad spectrum contribution to control in the malarial, Plasmodium falciparum, life cycle's infectious stages. It has been previously shown also that when the cultivated biologic source, Arteminisia annua, at bi-annual yields up to a 1% - 2% by weight of the Arteminisin active malariacide. Arteminisin is a double lactone phytochemical that when used by itself and in combination antiresistant treatment of fulminating neural malaria has been shown to be the therapy of choice. Recognizing that cultivation can be the primary source of this needed therapy, Arteminisia annua, can be harvested in a haystack bale by baler; the separatory process for the Arteminisin active molecule follows on a straightforward known procedure. Recent genetic engineering (GM) additions of the genome in E. coli have proven mainly the production of precursors to Arteminisin. Some of these precursors may be available for organic synthesis to deriviatives of Arteminisin--as Arteminisinic acid, and di-hydro Arteminisin though the active molecule shows the most effect. Because of double lactone ring structure in Arteminisin that must be active in malaria therapy--understood as very likely introducing an ozone like free radical intermediary into the Plasmodium falciparum. The actual extraction in acidic ethanol and into hexane would be accepted other track for Arteminisin availability followed by hemi-succinate esterifying to the hemi-succinate form allowed to precipitate. This becoming part of the agribusiness economy would integrate a supplemental agronomy study in engineering and economics. Furthermore any international uncertainties interrupting the supply of anti-malarials will be avoided with the source kept within American purview or western hemi-spheric bio-availability.

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